Protein Z/Z-dependent protease inhibitor (PZ/ZPI) anticoagulant system and thrombosis
نویسندگان
چکیده
منابع مشابه
Protein Z-dependent protease inhibitor W303X mutation in venous thrombosis.
In reply to the study by Gonzalez-Conjero et al, we found their results on 218 Spanish White patients very interesting. As suggested in their article, there does indeed appear to be an ethnic bias and possible founder affect with regard to the W303X mutation in thrombosis patients. The frequency of both the Factor V Leiden mutation and the prothrombin 20210A variant also varies within White pop...
متن کاملProtein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis.
To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ an...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Characterization of the protein Z–dependent protease inhibitor
Protein Z-dependent protease inhibitor (ZPI) is a 72-kd member of the serpin superfamily of proteinase inhibitors that produces rapid inhibition of factor Xa in the presence of protein Z (PZ), procoagulant phospholipids, and Ca11 (t1/2 less than 10 seconds). The rate of factor Xa inhibition by ZPI is reduced more than 1000-fold in the absence of PZ. The factor Xa–ZPI complex is not stable to so...
متن کاملA nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis.
The protein Z-dependent protease inhibitor (ZPI) is a hemostatic serpin with anticoagulant activity. As for antithrombin, deficiency of ZPI could have relevant thrombotic consequences. We have studied 6 genetic modifications affecting the ZPI gene, identifying 5 haplotypes. Haplotype H5 is featured by a stop codon at position 67. The relevance of these genetic modifications and haplotypes in ve...
متن کاملThe protein Z/protein Z-dependent protease inhibitor complex.
Protein Z (PZ) is a vitamin K-dependent factor identified in human plasma in 1984 but it has no enzymatic activity. It is a cofactor of a serpin, the protein Z-dependent protease inhibitor (ZPI), and the complex PZ/ZPI inhibits activated factor X on phospholipid surfaces. In mice, the disruption of PZ or ZPI gene is asymptomatic, but enhances the thrombotic phenotype and mortality of other thro...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2007
ISSN: 0007-1048,1365-2141
DOI: 10.1111/j.1365-2141.2007.06548.x